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Age plays a crucial role in determining sterility. http://martin37rosie.blog.fc2.com/blog-entry-6.html are highly fertile in their mid-twenties. Fertility starts declining as one crosses 3 decades of getting old. The factors that promote sterility in case of both women and men are stress, smoking, alcoholism, Drug Addiction, obesity, under-weight, dieting etc. Issues like thyroid disease, diabetes, anemia etc may also make a guy or woman sterile.
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Secondary sterility - In this case, the couple has conceived previously; but is now unable to perform because of some fertility impairing physical or issue.